AMOS utilizes one central database, and one central patient registry, and accepts and aggregates messages from external laboratories and testing centers. For example, AMOS is already linked to Quest Diagnostics, LabCorp, and several other hospital systems. Any authorized user can be granted permission to view information on any patient in the system, from anywhere. Thus, AMOS functions as a regional, national, or even global health information exchange. And AMOS is the only RHIE with the option of having a built in, fully bidirectionally linked EMR.

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This means that users of the RHIE, can easily start using the EMR's features in their offices as well. And, any information entered in to the EMR, is immediately available in the RHIE, for access by any other user of the RHIE or the EMR! And all this, without any switching between systems. A provider using AMOS for RHIE can decide that they'd like to ePrescribe or document visits with the same system. Any prescriptions or documents entered are then immediately reflected in the patient's single RHIE record.

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AMOS can also be used to do aggregate reporting on single practices, regions, or even global patient populations.

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AMOS can also distribute information to other software systems through the use of Web Services.

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ASP.MD can work with existing RHIO's to provide low-cost EMR capabilities to local providers within the RHIO's area of coverage.